发明名称 |
METHOD FOR PRODUCING COMPOUND USEFUL FOR SYNTHETIC INTERMEDIATE FOR PRODUCING AZOLE ANTIFUNGAL AGENT |
摘要 |
<p>PURPOSE: Provided is a method for producing a compound useful for a synthetic intermediate for producing an azole antifungal agent used in the prevention and treatment of various fungal infection diseases. CONSTITUTION: The compound as a synthetic intermediate for an azole antifungal agent is represented by the following formula(27). The compound of formula(27) is obtained by the method comprising the steps of: reacting a compound represented by formula(12) or a salt thereof with chloromethyl lithium produced from chloroiodomethane or bromochloromethane, or with dimethyl-sulfoxonium methylide, diethyl-sulfoxonium methylide or diethylsulfonium methylide to form a compound of formula(13) or a salt thereof: reacting the compound of formula(13) or a salt thereof with 1,2,4-triazole or imidazole or a salt thereof to form a compound of formula(21) or a salt thereof; and removing the hydroxyl-protecting group Pr from the compound of formula(21) or a salt thereof. In the above formulae, R is methyl; each of R22 and R23 is a fluorine atom; Pr is a hydroxyl-protecting group; and A is CH or N.</p> |
申请公布号 |
KR100451067(B1) |
申请公布日期 |
2004.09.21 |
申请号 |
KR20020051834 |
申请日期 |
2002.08.30 |
申请人 |
EISAI CO., LTD. |
发明人 |
NAITO TOSHIHIKO;HATA KATSURA;KAKU YUMIKO;TSURUOKA AKIHIKO;TSUKADA ITARU;YANAGISAWA MANABU;TOYOSAWA TOSHIO;NARA KAZUMASA |
分类号 |
C07D233/60;A01N43/653;A01P3/00;A61K31/4164;A61K31/4196;A61P31/10;C07C43/176;C07C43/178;C07C45/00;C07C45/61;C07C45/67;C07C45/71;C07C49/82;C07C49/84;C07D213/70;C07D249/08;C07D303/18;C07D303/22;C07D403/06;C07D403/10;C07D409/06;C07D409/14;C07D413/06;C07D417/04;C07D417/06;C07D417/14;C07D513/04;C07D521/00;C07F7/18;(IPC1-7):C07C45/61 |
主分类号 |
C07D233/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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