FUSED RING PYRIDINE DERIVATIVE, METHOD FOR PRODUCING THE SAME AND USE OF THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a compound exhibiting an excellent CCR5 antagonistic effect, and useful as a preventing and treating agent of HIV infection to human peripheral blood monocyte cells, and especially of AIDS. SOLUTION: This compound or its salt is expressed by the formula [wherein, R1is a 5- or 6-membered ring; R3is H, a lower alkyl or a lower alkoxy; Z1is a 5- or 6-membered aromatic ring; Z2is a group expressed by Z2aW2Z2b(wherein, Z2aand Z2bare each O, S(O)m(wherein, (m) is 0, 1 or 2)), imino or a bonding; W2is an alkylene chain which may be substituted; (n) is 0 to 4 integer; Y is O, S(O)p(where (p) is 0, 1 or 2), CH2or NR4(wherein, R4is H, a hydrocarbon group, a heterocyclic ring or an acyl); and R2is amino of which nitrogen atom may be quaternized or oxidized. a nitrogen-containing heterocyclic ring group or the like]. COPYRIGHT: (C)2004,JPO&NCIPI