发明名称 |
Regional intestinal permeability model |
摘要 |
Permeability models and methods for creating the models are disclosed. The models include receiving as an input in vitro permeability and structure data for a particular compound. Then the data is mapped to at least one permeability. In some models the data is mapped to a plurality of permeabilities, each associated with a specific region in a mammalian GI tract. Some models may take into consideration solubility, permeability and at least one molecular descriptor associated with the compound of interest. |
申请公布号 |
US2004180322(A1) |
申请公布日期 |
2004.09.16 |
申请号 |
US20030332999 |
申请日期 |
2003.06.05 |
申请人 |
GRASS GEORGE M.;LEESMAN GLEN D.;NORRIS DANIEL A.;SINKO PATRICK J.;ATHWAL JEHANGIR;SAGE CARLETON;BREMER TROY;HOLME KEVIN;LEE YONG-HEE;LEE KYOUNG |
发明人 |
GRASS GEORGE M.;LEESMAN GLEN D.;NORRIS DANIEL A.;SINKO PATRICK J.;ATHWAL JEHANGIR;SAGE CARLETON;BREMER TROY;HOLME KEVIN;LEE YONG-HEE;LEE KYOUNG |
分类号 |
C12Q1/02;G01N33/483;G06F19/00;(IPC1-7):C12Q1/00;G01N33/48;G01N33/50 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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