发明名称 |
USE OF IL10 HAPLOTYPES FOR PREDICTING SUSCEPTIBILITY TO PROGRESSION OF HBV TO HCC |
摘要 |
<p>This invention relates to IL10 haplotypes for predicting susceptibility to progression of HBV to HCC and use thereof. Interleukin 10 (IL10) is a powerful Th-2 cell cytokine produced by lymphoid cells that exerts its functions by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNFA, TGFB, IL6, IL8 and IL12). Genetic association analysis of a well-characterized HBV cohort revealed that one of IL10 haplotypes, IL10-ht2, was strongly associated with hepatocellular carcinoma (HCC) occurrence in gene dose-dependent manner. The frequency of susceptible IL10-ht2 was much higher in HCC patients and significantly increased in order of susceptibility to HBV progression from chronic hepatitis to liver cirrhosis and HCC among hepatitis B patients. In addition, survival analysis clearly showed that the onset age of HCC was also accelerated among chronic hepatitis B patients who were carrying IL10-ht2. Increased IL10 production mediated by IL10-ht2 suggests that up-regulated IL10 accelerates progression of chronic HBV infection, especially to HCC development.</p> |
申请公布号 |
WO2004079010(A1) |
申请公布日期 |
2004.09.16 |
申请号 |
WO2004KR00446 |
申请日期 |
2004.03.03 |
申请人 |
SNP GENETICS, INC.;SHIN, HYOUNG-DOO;LEE, HYO-SUK |
发明人 |
SHIN, HYOUNG-DOO;LEE, HYO-SUK |
分类号 |
C12Q1/68;C12Q1/70;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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