SYSTEM FOR EVALUATING DRUG METABOLISM CAPACITY AND METHOD OF USING THE SAME

摘要

The amount of a drug consumed by a specific drug metabolic enzyme and/or the amount of its metabolite are measured by using a packing agent the surface of which is coated with a polymer showing a change in hydration force within a temperature range of from 0 to 80°C and controlling the temperature by using a chromatography having an aqueous mobile phase. According to this system, drug metabolism capacity can be exactly evaluated by a convenient procedure without undesirably affecting the environment.