发明名称 |
LIGANDS THAT BIND TO THE AMYLOID-.BETA. PRECURSOR PEPTIDE AND RELATED MOLECULES AND USES THEREOF |
摘要 |
The present invention provides a composition comprising an isolated F-spondi n polypeptide specifically bound to an APP or APLP polypeptide. The present invention further provides a composition comprising an isolated neurexin polypeptide specifically bound to an APP or APLP polypeptide. Also provided are methods of screening for modulators of the binding of an APP or an APLP polypeptide by F-spondin or neurexin proteins. Modulators of the binding of an APP or an APLP polypeptide by F-spondin or neurexin proteins may be useful i n the treatment or prevention of AD.
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申请公布号 |
CA2517767(A1) |
申请公布日期 |
2004.09.16 |
申请号 |
CA20042517767 |
申请日期 |
2004.03.03 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SUDHOF, THOMAS C.;HO, ANGELA |
分类号 |
A61K;A61K38/17;A61K39/395;C07K14/47;C07K14/81;C07K16/18;C12N15/12;G01N33/53;G01N33/68;(IPC1-7):C12N15/12 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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