Compounds of the fonnulas L-[-An-Z-X-Ww-]-D and B-[-Z-X-Ww-]-D, wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and/or excipient, and methods of delivery the drug D via the compounds.
申请公布号
WO03026577(A3)
申请公布日期
2004.09.16
申请号
WO2002US30282
申请日期
2002.09.24
申请人
SEATTLE GENETICS, INC.;SENTER, PETER, D.;TOKI, BRIAN, E.