发明名称 |
Method for the selective removal of acyl-functionality attached to the 2' hydroxy-group of paclitaxel-related derivatives |
摘要 |
A method for removing acyl-groups appended by an ester linkage to the 2'-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions. 2',7-bis-Monochloroacetylpaclitaxel analogs are converted to their corresponding 7-monochloroacetyl derivatives by treatment with alcohol under non-acidic conditions.
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申请公布号 |
US2004181079(A1) |
申请公布日期 |
2004.09.16 |
申请号 |
US20040491576 |
申请日期 |
2004.04.02 |
申请人 |
ERHARDT PAUL W;KLIS WIESLAW A;SARVER JEFFREY G |
发明人 |
ERHARDT PAUL W;KLIS WIESLAW A;SARVER JEFFREY G |
分类号 |
C07D305/14;(IPC1-7):C0735/14 |
主分类号 |
C07D305/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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