发明名称 Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
摘要 The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
申请公布号 US2004180815(A1) 申请公布日期 2004.09.16
申请号 US20030384120 申请日期 2003.03.07
申请人 NAKAJIMA SUANNE;TANG DATONG;WU FRANK;MIAO ZHENWEI;SUN YING;OR YAT SUN;WANG ZHE 发明人 NAKAJIMA SUANNE;TANG DATONG;WU FRANK;MIAO ZHENWEI;SUN YING;OR YAT SUN;WANG ZHE
分类号 A61K38/12;C07K5/12;(IPC1-7):A61K38/12 主分类号 A61K38/12
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