Assays for inositol phosphates

摘要

The present invention provides cell-based assays for inositol phosphates involving the preferential binding of radio-labeled inositol phosphates to a solid phase containing a scintillant within. The assay allows one to screen for inhibitors of inositol phosphate phosphatases or GPCRs which are coupled to phosphoinositide hydrolysis. The assays are fast, convenient, and avoid the column chromatography steps that prior art methods employed.