发明名称 QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS
摘要 The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R<1>, X, R<3>, x, and ring A are as defined in the present application.
申请公布号 WO2004078733(A1) 申请公布日期 2004.09.16
申请号 WO2004US06451 申请日期 2004.03.03
申请人 VERTEX PHARMACEUTICALS INCORPORATED;GONZALES, JESUS, E., III;WILSON, DEAN, MITCHELL;TERMIN, ANDREAS, PETER;GROOTENHUIS, PETER, DIEDERIK, JAN;ZHANG, YULIAN;PETZOLDT, BENJAMIN, JOHN;FANNING, LEV, TYLER, DEWEY;NEUBERT, TIMOTHY, DONALD;TUNG, ROGER, D.;MARTINBOROUGH, ESTHER;ZIMMERMANN, NICOLE 发明人 GONZALES, JESUS, E., III;WILSON, DEAN, MITCHELL;TERMIN, ANDREAS, PETER;GROOTENHUIS, PETER, DIEDERIK, JAN;ZHANG, YULIAN;PETZOLDT, BENJAMIN, JOHN;FANNING, LEV, TYLER, DEWEY;NEUBERT, TIMOTHY, DONALD;TUNG, ROGER, D.;MARTINBOROUGH, ESTHER;ZIMMERMANN, NICOLE
分类号 A61K31/517;A61K31/5377;A61K31/541;C07D;C07D239/91;C07D239/94;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/12;C07D405/14;C07D409/04;C07D409/12;C07D409/14;C07D413/02;C07D413/12;C07D417/02;C07D417/12;C07D417/14;C07D471/04;C07D487/04;C07D498/04 主分类号 A61K31/517
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