PROCESSES FOR PRODUCING CYCLIC BENZAMIDINE DERIVATIVE

摘要

A process for producing a fluorinated cyclic benzamidine derivative (A) or salt thereof, characterized by comprising the step of reacting a specific novel compound with ammonia or an imide; a process for producing a morpholine-substituted phenacyl derivative (B) or salt thereof, characterized by comprising reacting a specific novel compound with morpholine, reacting the reaction product with a halogenating reagent, and subjecting the resultant reaction product to a reaction for ketal elimination; a process for producing a cyclic benzamidine derivative (C) or salt thereof, characterized by coupling the compound (A) or salt with the compound (B) or salt in the presence of an ether or hydrocarbon; and a method of recrystallizing the cyclic benzamidine derivative (C) or salt, characterized by dissolving the compound (C) or salt in a mixed solvent comprising an alcohol and water or in a mixed solvent comprising an ether and water and adding water to the solution to precipitate crystals of the compound (C) or salt.