发明名称 |
SUBSTITUTED 8'-PYRIDINYL-DIHYDROSPIRO-[CYCLOALKYL]-PYRIMIDO [1,2-a] PYRIMIDIN-6-ONE AND 8'-PYRIMIDINYL-DIHYDROSPIRO-[CYCLOALKYL]-PYRIMIDO [1,2-a] PYRIMIDIN-6-ONE DERIVATIVES AND THEIR USE AGAINST NEUROGENERATIVE DISEASES |
摘要 |
<p>The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein: X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, a carbonyl group, a methylene group optionally substituted; R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted; R2 represents a benzene ring or a naphthalene ring; the rings being optionally substituted; R3 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; m represents 1 to 4 n represent 0 to 3 p represents 0 to 2 q represents 0 to 2, p+ q being inferior to 4. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3beta, such as Alzheimer disease.</p> |
申请公布号 |
WO2004078760(A1) |
申请公布日期 |
2004.09.16 |
申请号 |
WO2004EP03051 |
申请日期 |
2004.03.05 |
申请人 |
SANOFI-SYNTHELABO;MITSUBISHI PHARMA CORPORATION;GEORGE, PASCAL;LOCHEAD, ALISTAIR;SAADY, MOURAD;SLOWINSKI, FRANCK;YAICHE, PHILIPPE |
发明人 |
GEORGE, PASCAL;LOCHEAD, ALISTAIR;SAADY, MOURAD;SLOWINSKI, FRANCK;YAICHE, PHILIPPE |
分类号 |
A61K31/519;A61P25/28;C07D487/04;C07D487/10;(IPC1-7):C07D487/04 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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