发明名称 |
Identification of compounds that inhibit replication of human immunodeficiency virus |
摘要 |
The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
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申请公布号 |
US2004180893(A1) |
申请公布日期 |
2004.09.16 |
申请号 |
US20040783053 |
申请日期 |
2004.02.19 |
申请人 |
BALZARINI JAN MARIA RENE;VAHLNE ANDERS;HOGBERG MARITA;TONG WEIMIN |
发明人 |
BALZARINI JAN MARIA RENE;VAHLNE ANDERS;HOGBERG MARITA;TONG WEIMIN |
分类号 |
A61K31/164;A61P31/18;B01D15/34;B01D15/36;C07C237/06;C07C409/40;(IPC1-7):A61K31/537;A61K31/53;A61K31/495;A61K31/515;A61K31/445 |
主分类号 |
A61K31/164 |
代理机构 |
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地址 |
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