Methods of restoring telomere length and extending cell lifespan using nuclear transfer

摘要

This invention relates to methods for rejuvenating primary cells and for making primary cells of a different type having the same genotype as a primary cell of interest. Also encompassed are methods of re-cloning cloned mammals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent. Also included are methods for activating endogenous telomerase for the purpose of extending the life span of a primary cell.