发明名称 CRYSTALS OF TAXANE DERIVATIVE AND PROCESS FOR THEIR PRODUCTION
摘要 <p>A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-Ä(1S)-2-(dimethylamino)ethylidenedioxyÜ-5,20-epoxy-1-hydroxytax-11-en-13- yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-hydroxypropionate, which has characteristic peaks at diffraction angles (2 &thetas; ) of 6.2 DEG , 10.3 DEG , 10.7 DEG , 11.4 DEG , and 12.0 DEG in a powder X-ray diffraction pattern, and a method for preparing the aforementioned crystal, which comprises the step of performing crystallization by using an organic solvent selected from the group consisting of a ketone type solvent, a nitrile type solvent, and a mixture thereof, or a mixture of said organic solvent and water.</p>
申请公布号 EP1457492(A1) 申请公布日期 2004.09.15
申请号 EP20020785977 申请日期 2002.11.29
申请人 DAIICHI PHARMACEUTICAL CO., LTD. 发明人 UCHIDA,S.;TAKAYANAGI,Y.;ONO, MAKOTO
分类号 A61K31/443;A61P35/00;C07D493/04;(IPC1-7):C07D493/04;C07D493/08 主分类号 A61K31/443
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