TREATMENT OF HUMAN SOFT TISSUE SARCOMA WITH ADENOVIRAL VECTOR EXPRESSING TNF-ALPHA

摘要

The present invention provides a method for reducing the size of a tumor in a human comprising (a) directly injecting into the tumor, via multiple injections to different points of the tumor, a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding TNF-alpha operably linked to a promoter, wherein the dose comprises about 1x107 to about 4x1012 3 particle units (pu) of replication-deficient adenoviral vector, two or more times over a therapeutic period comprising up to 10 weeks, and (b) administering a dose of ionizing radiation over the duration of the therapeutic period, whereby the size of the tumor is reduced.