发明名称 |
COMPOSITIONS AND METHODS FOR PREVENTING TRANSEPITHELIAL TRANSMISSION OF HIV |
摘要 |
Methods, compositions and articles for blocking transepithelial transmission of HIV with ICAM-1 angonist/antagonists are provided. The ICAM-1 agonist/antagonists block viral transmission at the site of exposure to the virus. Blocking viral transmission does not require blocking the binding of ICAM-1 to LFA-1. The ICAM-1 agonist/antagonists may be applied to mucosal surfaces, on or in contraceptive devices or in oral solutions such as breast milk supplements and infant formula. |
申请公布号 |
EP1190101(A4) |
申请公布日期 |
2004.09.15 |
申请号 |
EP20000944817 |
申请日期 |
2000.06.23 |
申请人 |
THE JOHNS-HOPKINS UNIVERSITY |
发明人 |
MARKHAM, RICHARD, B.;KHANNA, KRISTEN, V. |
分类号 |
A61K9/02;A23L33/00;A61K9/06;A61K9/08;A61K9/10;A61K9/12;A61K9/20;A61K39/395;A61P31/18;C07K16/28;C12N5/08 |
主分类号 |
A61K9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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