THERAPEUTIC AGENT FOR TREATMENT OF RHEUMATOID ARTHRITIS CONTAINING (-)-EPIGALLOCATECHIN GALLATE AS EFFECTIVE INGREDIENT

摘要

PURPOSE: A composition containing epigallocatechin gallate (EGCG) as one of green tea polyphenols as an effective ingredient is provided. The EGCG controls an inflammatory reaction in the lesion area of rheumatoid arthritis and a cell-mediated immune reaction which specifically reacts with an antigen and thus has a therapeutic effect on rheumatoid arthritis. CONSTITUTION: The agent for the treatment of rheumatoid arthritis contains (-)-epigallocatechin gallate and a pharmaceutically acceptable carrier such as physiological saline. The dosage of EGCG is 1 to 100mg/kg. The EGCG is administered in the form of an EGCG-PLGA complex by impregnating into a PLGA(poly/lactide/glycolide) polymer.