Process for preparing indolopyrrolocarbazole derivatives, intermediates therefor, and preparation process of the intermediates

摘要

A process for preparing indolopyrrolocarbazole derivatives [I] by trating a compound [V] with a base in an inert solvent to prepare a compound [IV], reacting the compound [IV] with a compound [III]to prepare a compound [II], and deblocking the compound [II]; intermediates [II], [III] and [IV]; and a process for preparing compounds [III]: [wherein Y<1 >is hydrogen, C1-4 alkyl, phenyl, benzyloxymethyl, or aralkyl; R<1>, R<2>, R<3>, R<4>, R<5>, and R<6 >are each independently a hydroxyl-protecting group; R<7 >and R<8 >are each independently hydrogen or a hydroxyl-protecting group; and X is an acid molecule]. The above process is a safe and easy industrial process for preparing indolopyrrolocarbazole derivatives [1] useful as antitumor agents.