Conjugates useful for treating gastrointestinal tumours such as colorectal tumours comprises an antibody such as C242 antibody and a toxin such as ricin A. The antibody and toxin may be coupled by a linker. Pharmaceutical compositions containing the conjugates and processes for their preparation are also inculded as well as methods of treating gastrointestinal tumours.
申请公布号
CA2073113(C)
申请公布日期
2004.09.14
申请号
CA19922073113
申请日期
1992.07.03
申请人
IMPERIAL CHEMICAL INDUSTRIES PLC;KABI PHARMACIA AB
发明人
WRIGHT, ANDREW F.;BLAKEY, DAVID C.;LIND, PETER;HOLMGREN, JAN;FITTON, JOHN E.;LINDHOLM, LEIF
