| 摘要 |
FIELD: biotechnology, biochemistry. ^ SUBSTANCE: method for stereoselective reduction of racemic 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthaleon involves interaction of indicated tetralone with microorganism or enzyme. Method involves using microorganism taken among the group consisting of Hansenula polymorpha ATCC 26012, Hansenula polymorpha ATCC 74449, Absidia coerulea ATCC 20137, Geotrichum candidum ATCC 34614, Geotrichum candidum ATCC 62401, Mortierella isabellina ATCC 42613, Mortierella isbellina ATCC 38063, Mortierella vinacea ATCC 09515, Penicillium notatum ATCC 36740, Blastoschizomyces capitatus ATCC 28575, Monosporium olivaceum v. major ATCC 36300, Aureobasidium pullulans ATCC 16623, Debaryomyces polymorphus ATCC 20280, Saccharomyces cerevisiae ATCC 15248, Candida schatavii ATCC 24409, Pichia fabianii ATCC 16755 and Streptomyces rimosus ss. Rimosus ATCC 10970. Method elicits stereoselectivity and provides high yield of product that can be used in synthesis of sertraline. ^ EFFECT: improved reducing method. ^ 35 cl, 3 tbl, 3 ex |
