发明名称 |
PROCESS FOR PREPARING 5-'(R)-2-(5,6-DIETHYL-INDIAN-2-YLAMINO)-1-HYDROXY-ETHYL!-8-HYDROXY-(1H)-QUINOLIN-2-ONE SALT, USEFUL AS AN ADRENOCEPTOR AGONIST |
摘要 |
<p>A process for preparing 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one salt. The process involves forming an acid salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-substituted oxy-(1 H)-quinolin-2-one (V); and converting the acid salt to a salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one (VI) without isolating the free base of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one. Formula (A); (V): R = a protecting group, (VI): R = H.</p> |
申请公布号 |
WO2004076422(A1) |
申请公布日期 |
2004.09.10 |
申请号 |
WO2004EP01981 |
申请日期 |
2004.02.27 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH;LOHSE, OLIVIER;VOGEL, CASPAR |
发明人 |
LOHSE, OLIVIER;VOGEL, CASPAR |
分类号 |
C07D215/26;(IPC1-7):C07D215/26 |
主分类号 |
C07D215/26 |
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