METHOD OF PREPARATION OF TERFENADINE AND ITS DERIVATIVES
摘要
The invention relates to a new method of preparation of derivatives of piperidinyl butylphenylacetic acids. The compounds are histaminically active. The substances are prepared by Grignard reaction of alkylhalohydrins and suitably substituted aromatic aldehydes. The resulting diols are subjected to subsequent substitution reaction.
申请公布号
WO2004043922(A8)
申请公布日期
2004.09.10
申请号
WO2003SK00021
申请日期
2003.11.07
申请人
ZENTIVA, A.S.;VEVERKA, MIROSLAV;BOHAC, ANDREJ;KRIZ, MIROSLAV;VARGA, IVAN
发明人
VEVERKA, MIROSLAV;BOHAC, ANDREJ;KRIZ, MIROSLAV;VARGA, IVAN