发明名称 |
New antimicrobial peptide papillosin, useful for treating infections by Gram positive or negative bacteria or fungi, in humans, animals or plants |
摘要 |
<p>An isolated peptide (I), designated papillosin, and its derivatives and fragments are new. Isolated peptide of formula (I), designated papillosin, and its derivatives and fragments are new. Gly-Phe-Trp-Lys-Lys-Val-Gly-Ser-Ala-Ala-Trp-Gly-Gly-Val-Lys-(Ala) 3-Lys-Gly-Ala-Ala-Val-Gly-Gly-Leu-Asn-Ala-Leu-Ala-Lys-His-Ile-Gln (I) Independent claims are also included for the following: (1) isolated polypeptide (II) that includes (I); (2) isolated polynucleotide (III) that encodes (I) or (II); (3) cloning and/or expression vector that contains (III); (4) host organism that contains a vector of (3) or (III); (5) plant cell resistant to microbial disease that contains (III) or expresses (I) or (II); and (6) plant containing at least one cell of (5). ACTIVITY : Antibacterial; Fungicide; Plant Antibacterial; Plant Antifungal. The minimum bactericidal concentration of (I), in MicroM, was 0.125-0.25 against M. luteus; 0.5-1 against S. aureus and 0.25-0.5 against E. coli DH5alpha . MECHANISM OF ACTION : Bacteriolysis.</p> |
申请公布号 |
FR2852013(A1) |
申请公布日期 |
2004.09.10 |
申请号 |
FR20030002714 |
申请日期 |
2003.03.05 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS |
发明人 |
MITTA GUILLAUME;GALINIER RICHARD;BANAIGS BERNARD;LASSERRE ERIC |
分类号 |
A61K38/00;A61P31/00;A61P31/04;C07K14/435;C12N15/12;(IPC1-7):C07K14/435;A01H5/00;A01N37/18;C12N15/63;C12N1/10;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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