发明名称 |
PROCESS FOR THE PREPARATION OF A bgr;-LACTAM NUCLEUS AND THE APPLICATION THEREOF. |
摘要 |
The invention relates to a process for the preparation of an aqueous solution or suspension of a bgr;-lactam nucleus and application thereof. The aqueous solution or suspension of the bgr;-lactam nucleus is prepared by process wherein an enzymatic deacylation of a bgr;-lactam compound, which compounds comprises a bgr;-lactam nucleus with a side chain coupled to it via an amide bond and which deacylation reaction is carried out in a mixture of water and an organic solvent and which deacylation leads to a bgr;-lactam nucleus and a carboxylic acid, is carried out at a pH value of between 2 and 6 so that the carboxylic acid is extracted in situ to the organic solvent. |
申请公布号 |
MXPA03001712(A) |
申请公布日期 |
2004.09.10 |
申请号 |
MX2003PA01712 |
申请日期 |
2001.08.27 |
申请人 |
DSM N.V. |
发明人 |
HEIJNEN, JOSEPH, JOHANNES |
分类号 |
C12N9/84;C12P35/02;C12P37/06 |
主分类号 |
C12N9/84 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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