POLYPEPTIDES AND METHODS FOR MAKING THE SAME

摘要

An isolated protein having at least 90 % homology with the dimeric protein having the following amino acid sequence (I) with the proviso that at the C-terminal end of the monomeric forms, 2 to 10 amino acid distance from Z<2>, a Cys is present for forming the dimeric or multimeric protein, Z<1> is a signal peptide for protein transport to the ER and/or through the plasma membrane or NH2 or a derivative of an NH2 group such as an alkylated, or acylated derivative, or polyethylene glycol (PEG) moiety, Z<2> is an amino acid residue with up to 20, in particular 10 or 8 amino acids which are selected of substantially non-hydrophobic naturally occurring amino acids or COOZ<3 >wherein Z<3> is hydrogen, a metal ion, a hydrocarbon moiety substituted or non-substituted with heteroatoms.