| 摘要 |
A pharmaceutical composition for alleviating tissue hypoxia, comprising (1) alpha-globin having the Titusville mutation, (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of the alpha-globin having the Titusville mutation, or (3) an expression vector comprising the polynucleotide, and a pharmaceutically acceptable carrier or diluent, is disclosed. Further, a method for alleviating tissue hypoxia comprising administering the same to a subject, and a transgenic non-human animal having expressably a polynucleotide comprising a base sequence encoding an amino acid sequence of alpha-globin having the Titusville mutation, are disclosed.
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