发明名称 |
Novel process for preparing rac-bicalutamide and its intermediates |
摘要 |
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio)propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof.
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申请公布号 |
US2004176638(A1) |
申请公布日期 |
2004.09.09 |
申请号 |
US20040796822 |
申请日期 |
2004.03.08 |
申请人 |
DOLITZKY BEN-ZION;REANY OFER;SHAMMAI JENNY |
发明人 |
DOLITZKY BEN-ZION;REANY OFER;SHAMMAI JENNY |
分类号 |
C07C69/675;C07C231/02;C07C231/08;C07C255/49;C07C255/50;C07C255/58;C07C315/04;C07C317/14;C07C317/44;C07C317/46;C07C317/48;C07C317/50;C07C319/14;C07C323/52;C07F1/02;(IPC1-7):C07F1/02 |
主分类号 |
C07C69/675 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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