发明名称 |
NIF-1 is a novel co-transducer that interacts with and regulates the activity of the nuclear hormone receptor co-activator, NRC |
摘要 |
The present invention relates to isolated human and rat nucleic acid molecules encoding a protein or polypeptide that modulates transcriptional activation in a cell with or without collaboration with a nuclear hormone receptor transcriptional co-activator. The present invention also relates to the proteins or polypeptides encoded by those nucleic acid molecules, and antibodies against such proteins or polypeptides. The present invention also relates to a variety of uses for the nucleic acid molecules, proteins or polypeptides, and the related antibodies of the present invention, including methods of: regulating cellular proliferation, differentiation, and development; modulating the activity of a transcriptional co-activator complex and a transcription factor in cells; regulating hormone receptor activity and endocrine function in cells; and treating diabetes and insulin resistance in a subject.
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申请公布号 |
US2004175720(A1) |
申请公布日期 |
2004.09.09 |
申请号 |
US20030645250 |
申请日期 |
2003.08.20 |
申请人 |
MAHAJAN MUKTAR A.;SAMUELS HERBERT H. |
发明人 |
MAHAJAN MUKTAR A.;SAMUELS HERBERT H. |
分类号 |
C07K14/47;(IPC1-7):C12Q1/68;C07H21/04;C12N9/22 |
主分类号 |
C07K14/47 |
代理机构 |
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