| 摘要 |
The invention provides novel methods of detecting PrP<Sc>. More specifically, the invention provides novel methods of detecting PrP<Sc >in eye fluid extracted from an eye globe of an animal. In contrast to previously known methods, the methods of the invention are readily performed on living animals, thereby facilitating the diagnosis of PrP<Sc>-associated disease prior to death. The methods also feature the decreased presence of antigen-binding factors, which could block antibody-antigen interactions, as well as lower background PrP<c>.
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