发明名称 |
Therapeutic platelets and methods |
摘要 |
A dehydrated composition is provided that includes freeze-dried platelets. The platelets are loaded with trehalose which preserves biological properties during freeze-drying and rehydration. The trehalose loading is conducted at a temperature of from greater than about 25° C. to less than about 40° C., most preferably at 37° C., with the loading solution having trehalose in an amount from about 10 mM to about 50 mM. These freeze-dried platelets are substantially shelf-stable and are rehydratable so as to have a normal response to an agonist, for example, thrombin, with virtually all of the platelets participating in clot formation within about three minutes at 37° C.
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申请公布号 |
US2004175374(A1) |
申请公布日期 |
2004.09.09 |
申请号 |
US20040802099 |
申请日期 |
2004.03.16 |
申请人 |
WOLKERS WILLIEM F.;CROWE JOHN H.;TABLIN FERN;OLIVER ANN E.;WALKER NAOMI J. |
发明人 |
WOLKERS WILLIEM F.;CROWE JOHN H.;TABLIN FERN;OLIVER ANN E.;WALKER NAOMI J. |
分类号 |
A01N1/02;A61K35/14;A61K47/48;(IPC1-7):A01N1/02;A61K45/00 |
主分类号 |
A01N1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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