| 摘要 |
PROBLEM TO BE SOLVED: To obtain an agent for treating and/or preventing diseases based on retinal ischemia. SOLUTION: (±)-2-Methoxyethyl 3-phenyl-2-(E)propenyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (cilnidipine) almost perfectly inhibited a retinal ischemia reperfusion damage in a retinopathy rat model due to transient retinal ischemia. Thereby, the cilnidipine can be used for treating or preventing diseases (for example, glaucoma, diabetic retinopathy, hypertensive retinopathy, macular degeneration or retinal vascular occlusion) caused by the retinal ischemia. COPYRIGHT: (C)2004,JPO&NCIPI
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