| 发明名称 |
Regioselective liquid phase pegylation |
| 摘要 |
A method is described for a method for the regioselective liquid-phase pegylation of GRF, which increases the yield of the GRF-PEG conjugate having 1 PEG molecule covalently bound to the e-amino group of Lys<12>. This method is characterized in that the reaction is carried out in a structuring solvent, such as trifluorethanol.
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| 申请公布号 |
US2004176569(A1) |
申请公布日期 |
2004.09.09 |
| 申请号 |
US20030398397 |
申请日期 |
2003.09.03 |
| 申请人 |
PIQUET GILLES;BARBERO LUCA;TRAVERSA SILVIO;GATTI MONICA |
发明人 |
PIQUET GILLES;BARBERO LUCA;TRAVERSA SILVIO;GATTI MONICA |
| 分类号 |
C07K14/60;A61K47/48;C07K1/08;C07K17/08;(IPC1-7):C07K14/475;C07K1/04 |
主分类号 |
C07K14/60 |
| 代理机构 |
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