Antagonists of RF-amide neuropeptides

摘要

Disclosed are compounds having the formula: where R1 =H, C1-C6 alkyl, cycloalkyl, R2 =H, C1-C6 alkyl, cycloalkyl W=CnH2n-m-NH (n=1-6, m=0, 2, or 4), X= R3= Y= Z=CONR8(CH2)n, CONR8(CH2)nCO, P(CH3)OCHR8OCOR9, SO2, SO2(CH2)n, SO2(CH2)nCO, SO2NR8(CH2)n, SO2NR8(CH2)nCO, n=1-4 R4=H, (CH2)nOH, (CH2)nOCOR10, (CH2)nNR10R11, (CH2)nCONR10R11, n=0-4 R5=H, (CH2)nNR12R13, n=0-4 R6=H, (CH2)nNR14R15, n=0-4 R7 =H, C1-C6 alkyl, cycloalkyl; R8 =H, C1-C6 alkyl, cycloalkyl; R9=H, C1-C6