| 发明名称 |
Methods for direct detection of individual methotrexate metabolites |
| 摘要 |
The present invention provides a method for determining a level of a methotrexate polyglutamate (MTXPG) in a cellular extract by resolving at least one MTXPG in a cellular extract obtained from a human undergoing methotrexate therapy; and detecting at least one resolved MTXPG, thereby determining a level of the resolved MTXPG. A method of the invention can be useful, for example, for determining a level of MTXPG3, MTXPG4 or MTXPG5 or for determining a level of each methotrexate polyglutamate species (MTXPG1 to MTXPG7) present in the cellular extract.
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| 申请公布号 |
US2004175834(A1) |
申请公布日期 |
2004.09.09 |
| 申请号 |
US20030384066 |
申请日期 |
2003.03.07 |
| 申请人 |
DERVIEUX THIERRY;RICHERSON RUSSELL B. |
发明人 |
DERVIEUX THIERRY;RICHERSON RUSSELL B. |
| 分类号 |
A01N1/02;C12Q1/00;C12Q1/02;G01N;G01N21/62;G01N21/75;G01N30/02;G01N33/00;G01N33/48;G01N33/94;(IPC1-7):G01N33/00 |
主分类号 |
A01N1/02 |
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