发明名称 |
Use of p38/JTV-1 for treating cancer |
摘要 |
This invention relates to a novel use of p38/JTV-1. More particularly, the invention relates to a p38/JTV-1 protein for use as medicament, a nucleic acid encoding for said protein, and a method for screening a pharmaceutical composition for the treatment of cancer characterized by selecting a substance having an effect on the increase in the activity of the p38/JTV-1 protein or the intracellular level thereof. The p38/JTV-1 according to the invention can be usefully used to treat cancer through the mechanism of suppressing the proliferation of cancer cells by binding to FBP (FUSE-binding protein) and thereby promoting the ubiquitination of FBP to downregulate c-myc gene, which is a proto-oncogene, and the mechanism of promoting the apoptosis of cells by binding to PDK-1 (phosphoinositide-dependent protein) and thereby inhibiting the phosphorylation of AKT (serine/threonine kinase). Also, p38/JTV-1 can be used as a target for screening of new anticancer agents, by virtue of such regulation mechanisms of p38/JTV-1. <IMAGE>
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申请公布号 |
EP1454628(A2) |
申请公布日期 |
2004.09.08 |
申请号 |
EP20030020344 |
申请日期 |
2003.09.09 |
申请人 |
SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION |
发明人 |
KIM, SUNGHOON;PARK, BUM-JOON |
分类号 |
G01N33/50;A61K35/76;A61K38/00;A61K38/16;A61K38/18;A61K48/00;A61P35/00;A61P35/02;A61P43/00;C12N15/09;C12Q1/02;G01N33/15;G01N33/574;(IPC1-7):A61K38/17 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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