发明名称 |
PHARMACEUTICAL DOSAGE FORM WITH MULTIPLE COATINGS |
摘要 |
<p>The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) 1:2, poly(methacrylic acid, methyl methacrylate) 1:1, and mixtures thereof; and c. an outer coating layer comprising an enteric polymer or film coating material; wherein the inner coating layer is not the same as the outer coating layer; wherein if the inner coating layer is poly(methacrylic acid, methyl methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, methyl methacrylate) 1:2 or is not a mixture of poly(methacrylic acid, methyl methacrylate) 1:1 and poly(methacrylic acid, methyl methacrylate) 1:2; and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent. This invention further relates to a method of maintaining the desired site of delivery of a therapeutic agent in the gastrointestinal tract by administering the above compositions to a human or lower animal.</p> |
申请公布号 |
EP1453487(A1) |
申请公布日期 |
2004.09.08 |
申请号 |
EP20010995903 |
申请日期 |
2001.11.23 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
DITTMAR, GREGORY, PAUL;AMANTE, JOSEPH, MICHAEL;CRONK, TONY RYAN;NEWBY, DANIEL, GARY |
分类号 |
A61K9/32;A61K;A61K9/28;A61K9/36;A61K9/48;A61K31/606;A61K45/00;A61K47/32;A61P1/00;A61P1/04;(IPC1-7):A61K9/28 |
主分类号 |
A61K9/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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