| 摘要 |
Described is a method for determining the function of a gene. This method involves determining the amount of transcript for each of a set of candidate genes in samples taken from different phenotypic and/or genotypic states of an organism and determining the amount of each of a plurality of metabolites in different samples taken from the same states as those mentioned above. Subsequently, the data obtained is analyzed by suitable mathematical methods in order to identify a transcript and metabolites which correlate in the different states, thereby identifying a transcript corresponding to a gene which influences the amount of metabolites in the organism. Furthermore described is a method for identifying a gene which is capable of modifying the amount of a metabolite in an organism and to a method for identifying a metabolite which is capable of modifying the amount of a transcript in an organism. Likewise, uses of the genes and metabolites identified in the aforementioned methods are described.
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