ASPARTIC ACID DERIVATIVES, THEIR PREPARATION AND USE

摘要

Aspartic acid derivatives of the formula (see formula I) in which X denotes, for example, (see formula II) and R denotes, for example, cyclohexylamino, have useful pharmacological properties. In particular, they have the ability to inhibit the binding of fibrinogen, fibronectin and von Willebrand factor to integrin receptors. They also inhibit platelet aggregation, metastasis of carcinoma cells and osteoclast formation on bone surfaces and are useful in prophylaxis and therapy of, for example, arterial vascular diseases and in the treatment of tumors.