发明名称 |
Mutant human hepatitis B viral strain and uses thereof |
摘要 |
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-'S'-133 Oon Strain (Methionine to Threonine) which constituent viral genome is deposited under Accession Nos. P97121501, P97121502 and P97121503 with the European Collection of Cell Culture on 15<th >December 1997. This invention also provides an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 133 of such polypeptide is a threonine rather than a methionine. This invention also provides an isolated nucleic acid which encodes a peptide, wherein the peptide is encoded by a nucleic acid molecule comprising nucleotides 527 through 595 of SEQ. I.D. No. 1 and the purified peptide. This invention also provides various methods of using the disclosed isolated nucleic acid and peptides.
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申请公布号 |
US6787142(B2) |
申请公布日期 |
2004.09.07 |
申请号 |
US20020209264 |
申请日期 |
2002.07.31 |
申请人 |
GOVERNMENT OF REPUBLIC OF SINGAPORE |
发明人 |
OON CHONG JIN;LIM GEK KEOW;ZHAO YI;CHEN WEI NING |
分类号 |
A61K38/00;C07K1/22;C07K14/02;(IPC1-7):A61K39/29;A61K39/42;C07K14/00;C07K14/01;C07K14/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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