| 摘要 |
<p>The present invention relates to a process for producing Simvastatin comprising the steps of acylating 6(R) [2 (8apos;(S) hydroxy 2apos;(S), 6apos;(R) dimethyl 1apos;,2apos;,6apos;,7apos;,8apos;, 8apos;a(R) hexahydronaphthyl 1apos;(S)ethyl 4(R) t butyldimethylsily loxy 3,4,5,6 tetrahydro 2H pyran 2 on with the carboxylic acid compound of formula (VI) wherein R is methyl, ethyl, propyl, n butyl, t butyl or phenyl, and hydroxylating the resulting compound.</p> |
