| 发明名称 |
SOLUTION AND CRYSTAL STRUCTURES OF MMP-13 ACTIVE SITE AND USES THEREOF |
| 摘要 |
The present invention relates to the three dimensional structure of human collagenase 3 (MMP-13), as well as to (i) methods of using the MMP-13 structure to rationally design or identify compounds or molecules that inhibit or activate MMP-13 activity, and (ii) compounds identified using said methods. |
| 申请公布号 |
PL359819(A1) |
申请公布日期 |
2004.09.06 |
| 申请号 |
PL20010359819 |
申请日期 |
2001.02.16 |
| 申请人 |
WYETH CORP |
发明人 |
CHEN JAMES M;MOBILIO DOMINICK;MOY FRANKLIN J;PARRIS KEVIN D;POWERS ROBERT;BAO XU ZHANG |
| 分类号 |
G01N33/50;A61K31/343;A61K45/00;A61P19/02;A61P35/00;A61P43/00;C07D307/85;C12N9/64;C12Q1/37;G01N33/15 |
主分类号 |
G01N33/50 |
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