METHOD FOR PRODUCING PHENYL PROPIONIC ACID DERIVATIVES WITH HIGH YIELD AND PURITY

摘要

PURPOSE: Provided is a method for producing phenyl propionic acid derivatives, particularly 2-(4-halomethylphenyl)propionic acid by simple and minimized processing steps with high yield and purity. CONSTITUTION: The method for producing 2-(4-halomethylphenyl)propionic acid represented by formula 1 comprises a step of reacting 2-phenylpropionic acid represented by formula 2 in the presence of hydrogen halide and a hydroformylating agent. In formula 1, X is Cl, Br or I. Particularly, the hydroformylating agent is selected from the group consisting of gaseous formaldehyde, formaldehyde solution, paraformaldehyde, trioxane and methanal, and is present in an equivalent ratio of 1-10 per equivalent of 2-phenylpropionic acid.