发明名称 |
Nonhuman pregnane x receptor sequences for use in comparative pharmacology |
摘要 |
Polynucleotides and polypeptides of canine, primate, porcine and fish pregnane X receptor (PXR), as well as expression vectors and host cells for expression of these PXR receptors, are provided. Also provided are methods for screening for modulators of these PXR receptors and using these receptors for comparative pharmacology and in selection of appropriate preclinical animal models predictive of human PXR activity.
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申请公布号 |
US2004171811(A1) |
申请公布日期 |
2004.09.02 |
申请号 |
US20030478551 |
申请日期 |
2003.11.21 |
申请人 |
KLIEWER STEVEN ANTHONY;MAGLICH JODI MARIE;MOORE JOHN TOMLIN;MOORE LINDA BECKER;WILLSON TIMOTHY MARK |
发明人 |
KLIEWER STEVEN ANTHONY;MAGLICH JODI MARIE;MOORE JOHN TOMLIN;MOORE LINDA BECKER;WILLSON TIMOTHY MARK |
分类号 |
A01K67/027;C07K14/705;C07K16/28;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;G01N33/15;G01N33/50;(IPC1-7):C07K14/72;C07H21/04 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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