发明名称 |
IN VIVO FLUORESCENCE SENSORS, SYSTEMS, AND RELATED METHODS OPERATING IN CONJUNCTION WITH FLUORESCENT ANALYTES |
摘要 |
Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification. In particular embodiments, the intensity of the excitation signals emitted to the localized tissue can be varied in a predetermined manner to generate optical profiling data of the response of the tissue proximate the sensor. |
申请公布号 |
WO2004075032(A2) |
申请公布日期 |
2004.09.02 |
申请号 |
WO2004US05785 |
申请日期 |
2004.02.17 |
申请人 |
SICEL TECHNOLOGIES INC.;BLACK, ROBERT, D.;BOLICK, NATASHA |
发明人 |
BLACK, ROBERT, D.;BOLICK, NATASHA |
分类号 |
A61B5/00;A61K49/00 |
主分类号 |
A61B5/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|