DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PARATHYROID HORMONE RECEPTOR 1 (PTHR1)

摘要

The invention provides a human PTHR1 which is associated with the cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation, urological diseases, developmental disorders, cancer, metabolic diseases, endocrinological diseases and disorders of the gastroenterology system. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation, urological diseases, developmental disorders, cancer, metabolic diseases, endocrinological diseases and disorders of the gastroenterology system. The invention also features compounds which bind to and/or activate or inhibit the activity of PTHR1 as well as pharmaceutical compositions comprising such compounds.