发明名称 |
Method of the solid phase synhesis of pyrrole-imidazole polyamide |
摘要 |
It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.
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申请公布号 |
US2004171799(A1) |
申请公布日期 |
2004.09.02 |
申请号 |
US20030481275 |
申请日期 |
2003.12.19 |
申请人 |
SUGIYAMA HIROSHI;IIDA HIROKAZU;SAITO ISAO;SAITO TAKASHI |
发明人 |
SUGIYAMA HIROSHI;IIDA HIROKAZU;SAITO ISAO;SAITO TAKASHI |
分类号 |
C07D403/14;(IPC1-7):C07K1/02 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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