DIAGNOSIS AND THERAPY OF BREAST TUMOURS RESISTANT TO ANTIESTROGEN TREATMENT

摘要

The invention is about a method to diagnose and therapy breast tumors resistant to antiestrogen treatment by using specific target proteins and the nucleic acids encoding these proteins. The method is based on the determination of the differential expression of specific target genes on the nucleic acids and protein level in antiestrogen-resistant breast tumor cells. Fields of application exist in medicine and in the pharmaceutical industry. The method is characterized by the fact, that the concentration of at least one specific target protein is determined in tumor tissue and is compared with the standard reference value of the same protein or proteins in breast tumor tissue sensitive to antiestrogen treatment, whereat a protein concentration of the sample examined lying above the standard reference value indicates tumor resistance to antiestrogen treatment, provided it is a protein which is expressed at a higher level in breast tumor cells resistant to antiestrogen treatment, as compared to breast tumor cells sensitive to antiestrogen treatment, or a protein concentration of the sample examined lying below the standard reference value indicates tumor resistance to antiestrogen treatment, provided it is a protein which is expressed at a lower level in breast tumor cells resistant to antiestrogen treatment, as compared to breast tumor cells sensitive to antiestrogen treatment.