发明名称 |
Prodrugs activated by plasmin and their use in cancer chemotherapy |
摘要 |
The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by plasmin. Also disclosed are methods of making and using the prodrug compounds.
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申请公布号 |
US2004171562(A1) |
申请公布日期 |
2004.09.02 |
申请号 |
US20030362958 |
申请日期 |
2003.10.31 |
申请人 |
TROUET ANDRE;DUBOIS VINCENT;PASSIOUKOV ALEXANDRE |
发明人 |
TROUET ANDRE;DUBOIS VINCENT;PASSIOUKOV ALEXANDRE |
分类号 |
A61K38/06;A61K38/07;A61K38/08;A61K47/48;(IPC1-7):A61K48/00;C07H21/04 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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